Fig 1: Mutation of IGF2BP3 attenuates the tumourigenesis of cervical cancer. (A) Representative images of tumour spheroids formation from HeLa‐Parkin cells expressing wild‐type or mutant IGF2BP3. Scale bar 250 μm. (B) Nude mice were subcutaneously injected with HeLa‐Parkin cells expressing wild‐type or mutant IGF2BP3 to establish a xenograft tumour model. Xenograft tumour volumes were measured twice per week and then quantified and statistically analysed. **p < 0.01. (C) Representative images of the xenograft tumours. (D) The excised tumours in the two groups were weighed and statistically analysed. (E) IHC staining of Ki‐67, MYC, FLAG and Parkin and H&E staining were performed on serial sections of tumour tissues in the two groups. (F) The protein levels of Ki‐67 and MYC in tumour tissues were analysed using ImageJ; and statistical analysis was performed.